Endocrine Abstracts

Various programming stimuli have been postulated to permanently influence fetal development with the common result that offspring exhibit differing degrees of insulin resistance. We set out to establish whether protein restriction, high glucose, glucocorticoid or alcohol exposure might exert their effects directly using a derived population of fetal hepatocytes. Cells were isolated from fetal mouse livers (n=10) at embryonic day 12. Fetal livers were rinsed in phosphate...